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A 2021 clinical trial published in Neurology and Therapy utilized a triple-blind, placebo-controlled crossover design —the highest standard in clinical research—to evaluate the impact of a single 200 mg dose of L-theanine on the human stress response. The study monitored 16 healthy adults (ages 18–60) to determine how the amino acid affects both neurological activity and hormonal markers. The researchers observed two primary physiological outcomes: Neurological Shift: Withi

A landmark 2019 study published in Nutrients conducted a randomized, double-blind, placebo-controlled crossover trial to investigate the long-term (4-week) effects of daily L-theanine supplementation. Unlike previous studies that focused on acute, one-time doses, this research measured how consistent use affects a non-clinical, healthy population. The researchers analyzed 30 adults taking 200 mg/day of L-theanine and found significant improvements across three key mental h

A 2024–2025 comprehensive review published in Nutrients provides an updated analysis of magnesium’s systemic role, focusing on its function as a natural "calcium antagonist." The research explores how organic forms, such as magnesium bisglycinate , are uniquely suited to manage conditions ranging from muscle hyper-excitability to metabolic syndrome. The review outlines the physiological mechanisms that make this form effective for whole-body health: Muscle Relaxation & Recov

A 2025 study published in Nutrients (MDPI) utilized a rigorous two-stage in vitro digestion model —mimicking the human stomach and small intestine—to determine which forms of magnesium are most effectively absorbed. The research specifically looked at how different "food matrices" (diets high in fiber, protein, or standard nutrients) affect the absorption of 12 different magnesium products, including organic chelates like magnesium bisglycinate . The researchers identified s

A 2025 systematic review published in Nutritional Neuroscience critically appraised 13 clinical trials (involving 550 participants) to determine the efficacy of L-theanine as a standalone sleep aid. The review sought to establish whether this non-protein amino acid could serve as a viable, non-sedative alternative to traditional pharmaceutical sleep interventions. The analysis led to several key scientific conclusions: Optimal Dosage Range: The review identified that daily